Jones has contributed to the long-running comics series Fables at DC/Vertigo, the Dark Horse anthologies Noir and Sexy Chix, and she drew the Minx young adult graphic novel Token, written by Alisa Kwitney. She has drawn two issues of the Eisner-nominated series Madame Xanadu, written by Matt Wagner, and worked with writer Zack Whedon on a comic book spin-off of the popular Dr. Horrible web series. She is currently working on a long-form comic for Vertigo called The Starving Artist, as well as Troublemaker, a collaboration with best-selling author Janet Evanovich that continues the writer's series of Alexandra Barnaby novels.
Joëlle Jones has also collaborated with Jamie S. Rich on the acclaimed comic book 12 Reasons Why I Love Her, and they have since shown up as a team in the pages of Popgun, Portland Noir, and Madman Atomic Comics. Joëlle also did the cover and interior illustrations for Jamie's novel Have You Seen the Horizon Lately?, and their most recent full-length effort was the acclaimed crime graphic novel, You Have Killed Me.